ACUTE TOXICITY ESTIMATION OF MULTICOMPONENT PLANT PROTECTION PRODUCTS USING CALCULATIONS, IN SILICO AND IN VIVO METHODS. PERSPECTIVES FOR UPDATING APPROACHES TO CLASSIFICATION AND RISK ASSESSMENT

Aim of study is to assess different alternative approaches to acute toxicity assessment of PPP, including calculation based on the assumption of additivity and in silico methods.Acute toxicity of eight PPP, containing from 2 to 5 active ingredients (AI) pesticides and number of co-formulants was assessed.In vivo studies of acute toxicity were condu

Micronuclei, comet and chromosome alterations assays are the most widely used biomarkers for determining the genotoxic damage in a population exposed to genotoxic chemicals.While chromosome alterations are an excellent biomarker to detect short- and long-term genotoxic effects, the comet assay only measures early biological effects, and furthermore

Acute rejection, a common complication of lung transplantation, may promote obliterative bronchiolitis leading to graft failure in lung transplant recipients.During acute rejection episodes, CD8(+) T cells can contribute to lung epithelial injury but the mechanisms promoting and controlling CD8-mediated injury in the lung are not well understood.To